Differentiated and simplified pre-exposure prophylaxis for HIV prevention: update to WHO implementation guidance

Overview

WHO recommends multiple pre-exposure prophylaxis (PrEP) options as part of combination prevention approaches and there has been a global uptake of PrEP into national guidelines and widespread implementation of PrEP services, although projects and programmes are still commonly small-scale. In many countries, services have been demedicalized, simplified, differentiated, digitalized, and integrated to increase uptake and effective use of PrEP.

This technical brief aims to support these trends, accelerated by the COVID-19 pandemic, and improve PrEP uptake, persistence, and effective use by providing implementation guidance for differentiated and simplified service delivery. The brief aims to support a range of stakeholders in planning and implementing PrEP services and supplements and updates previously published WHO PrEP implementation guidance.